2008-01-23

SSRI RISK GREATER THAN BENEFIT: New Systematic Review of Research – SSRIs vs Placebo Posted on February 21, 2017 February 21, 2017 by Ann Blake-Tracy Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. The meta-analysis of SSRI vs. placebo by Soomro et al. (2008) included 17 studies (3097 participants) and unequivocally demonstrated the efficacy of SSRIs in OCD. Analysis of 13 studies (2697 participants) indicated that SSRIs are nearly twice as likely as placebo to produce a clinical response (⩾25% reduction in YBOCS from baseline). A study just published in JAMA Jan 5, reported that SSRI antidepressants are no better than placebo for most cases of depression.

The studies meeting the criteria included 88,000 patients. For attempted suicide, the RR was 2.3 for SSRIs vs. placebo (95% CI, 1.14-4.55). The number needed to treat to harm (sometimes called the “reverse NNT”) was 1 in 684.

SSRIs can cause “diarrhoea, headaches, sleep problems and nausea” (“Depression: How effective…”, 2017, para. 6 2020-05-15 The Debate Is Over: Antidepressants DO Work Better Than Placebo.

The full study and editorial are linked to this news release. (SSRI) fluoxetine with placebo for reducing the frequency and severity of obsessive-compulsive behaviors in children and adolescents with autism spectrum disorder (ASD) in this randomized clinical trial in Australia. The trial included 146 participants

10 Nov 2015 While the efficacy of selective serotonin reuptake inhibitor (SSRI) SSRIs versus placebo in short-term treatment of unipolar depression were sought Six different SSRIs were studied in placebo-controlled trials with 17 Jan 2008 Among 74 FDA-registered studies, 31%, accounting for 3449 study participants, were not published. Whether and how the studies were 1 Aug 2003 A side effect of SSRIs coincidentally provides therapy for premature a systematic review to assess the efficacy of SSRIs versus placebo and av F Hieronymus · 2019 — superiority of selective serotonin reuptake inhibitors over placebo in reducing and v) that the net effect of antidepressants on suicidality is beneficial, at least in No rCBF differences were found between SSRI responders and placebo responders.

The review included 17 studies (3097 participants), and showed that SSRIs were effective in reducing the symptoms of OCD. Based on 13 studies (2697 participants), the review showed that people receiving SSRIs were nearly twice as likely as those receiving placebo to achieve clinical response (defined as a 25% or more reduction in symptoms).

Side-effects of SSRIs SSRIs have many more side-effects than placebo medication. SSRIs can cause “diarrhoea, headaches, sleep problems and nausea” (“Depression: How effective…”, 2017, para.

The authors reviewed 30 years of data and concluded that "the benefit of antidepressant medication compared with placebo may be minimal or nonexistent in patients with mild or moderate symptoms". 2019-10-22 This double-blind, placebo-controlled study examined the efficacy and tolerability of quetiapine in combination with selective serotonin reuptake inhibitors (SSRIs)/venlafaxine in 58 patients with major depressive disorder, comorbid anxiety symptoms (HAM-A-14 score > or =14), and residual depressive symptoms (HAM-D-17 score > or =18, CGI-S score > or =4). Angell cites research suggesting that antidepressants—including both selective serotonin reuptake inhibitors (SSRIs) and other medications—may not be any more effective than placebos for treating 2017-09-01 The impact of placebo factors in the treatment of anxiety can also be seen in a study by Faria et al. . Participants diagnosed with social anxiety disorder (SAD) were treated with an selective seratonin reuptake inhibitor (SSRI) (escitalopram).
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2019-10-22 This double-blind, placebo-controlled study examined the efficacy and tolerability of quetiapine in combination with selective serotonin reuptake inhibitors (SSRIs)/venlafaxine in 58 patients with major depressive disorder, comorbid anxiety symptoms (HAM-A-14 score > or =14), and residual depressive symptoms (HAM-D-17 score > or =18, CGI-S score > or =4). Angell cites research suggesting that antidepressants—including both selective serotonin reuptake inhibitors (SSRIs) and other medications—may not be any more effective than placebos for treating 2017-09-01 The impact of placebo factors in the treatment of anxiety can also be seen in a study by Faria et al. .

Now research suggests placebos may be as good as The relative merits of antidepressants versus placebo for depression have been Arroll et al (2005), who included only studies carried out in the primary health 27 Aug 2020 The small effect of antidepressants over placebo [10] is often believed to (A) Forest plot of the VR for each antidepressant versus placebo for 7 Mar 2019 In five trials of escitalopram versus placebo, Michael Thase et al. A meta- analysis of the effect of SSRIs on HRSD items in regulatory trials, health that readers seem to be hungry for-the antidepressant versus placebo antidepressants, with the reverse effect observed in those in the pill placebo 21 Feb 2018 The researchers found that every type of antidepressant they studied was more effective at lessening symptoms of depression over time than 2 Apr 2019 All antidepressants in the study were found to be superior to placebo.
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Background: Up to one half of depressed patients have partial or no response to antidepressant monotherapy. This multicenter, placebo-controlled study evaluated the efficacy of modafinil augmentation in major depressive disorder (MDD) patients with fatigue and excessive sleepiness despite selective serotonin reuptake inhibitor (SSRI) monotherapy.

A study just published in JAMA Jan 5, reported that SSRI antidepressants are no better than placebo for most cases of depression.